منابع مشابه
Cytotoxic cardiac glycosides and other compounds from Asclepias syriaca.
Phytochemical investigation of the dried biomass of Asclepias syriaca afforded five new compounds (1-5), along with 19 known structures. Overall, the secondary metabolites isolated and identified from this plant showed a wide structural diversity including pentacyclic triterpenes, cardiac glycosides, flavonoid glycosides, lignans, a phenylethanoid, and a glycosylated megastigmane. In addition, ...
متن کاملCardiac glycosides as novel cancer therapeutic agents.
The class of steroid-like compounds designated cardiac glycosides includes well-known drugs such as digoxin, digitoxin, and ouabain. Their continued efficacy in treatment of congestive heart failure and as anti-arrhythmic agents is well appreciated. Less well known, however, is the emerging role of this category of compounds in the prevention and/or treatment of proliferative diseases such as c...
متن کاملEffects of Cardiac Glycosides
Using microelectrodes having an external diameter of less than 1 ,u, potential variations of single caidiac fibers were obtained from frog ventriculai' muscle in situ. The normal membrane potential consists of a rapid depolarization and slow reecovery, the latter occurring in three distinct phases. Digitalis glycosides alter profoundly the slopes of these various phases and dlastically shorten ...
متن کاملThe Cardiac Glycosides
author offers no evidence to support his own contentions other than "laboratory studies show," "phylobiological investigations show," "my researches and those of my associates show." A really specific account of the therapeutic method to be used, or how the physiological method is to be applied, is found nowhere in the book, nor are any concrete case histories supplied. A much-needed glossary, ...
متن کاملCardiac glycosides and cardiomyopathy.
Digitalis-like steroids and related agents have been a mainstay in the treatment of congestive heart failure ever since the publication, in 1785, of Withering’s seminal monograph on foxglove. Heart failure refers to the clinical syndrome that results when the heart is unable to pump sufficient blood to keep up with the metabolic demands of the body. Congestive heart failure is characterized by ...
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ژورنال
عنوان ژورنال: Trends in Molecular Medicine
سال: 2020
ISSN: 1471-4914
DOI: 10.1016/j.molmed.2020.01.001